British number two, Dan Evans continued his losing streak against Japan’s Yoshihito Nishioka with a straight-set defeat in the Korea Open.
Evans, ranked 25 in the world, has lost all six of his meetings with Nishioka, who is 31 places lower.
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Nishioka, who capitalised on a dropped serve in the first game, won 6-2 7-6 (7-3) in the first round in Seoul.
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The 27-year-old has already beaten Evans, 32, in Miami and Washington this year.
Britain’s lucky loser, Ryan Peniston was also knocked out, beaten 6-3 7-6 (10-8) by Chile’s Nicolas Jarry, who will next face top seed Casper Ruud of Norway.