Defending champion Novak Djokovic, 13-time winner Rafael Nadal and new teenage star Carlos Alcaraz were drawn in the same half of Roland-Garros on Thursday.
World No 1 Djokovic and Nadal, ranked five, are seeded to meet as early as the quarterfinals.
Alcaraz, 19, is bidding to become just the eighth teenager to win a Grand Slam men’s title.
He could face either Djokovic or Nadal, who holds a record 21 majors, in the semifinals in a top-heavy draw for the second Grand Slam of the season.
“I am very motivated to play my best tennis,” said two-time Roland-Garros champion and 20-time major winner Djokovic.
“In Paris, I always play very strong. Last year, it was the toughest major that I had won.”