Cristiano Ronaldo scored his fourth goal in three matches since his return to Manchester United on Sunday before Jesse Lingard grabbed a late winner on his return to West Ham in a 2-1 win.
Ronaldo tapped in to cancel out Said Benrahma’s opener and substitute Lingard appeared to have won the match for the visitors in the 89th minute.
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But there was time for a late drama when the home side were awarded a penalty for a Luke Shaw handball in added time.
Mark Noble came on to take the spot-kick but Manchester United goalkeeper, David de Gea, dived to his left to keep it out, sparking a frenzy among United players.
The Red Devils have now moved into second place on the table, level on points with Liverpool.
Ronaldo was jeered and whistled by the home fans at the London Stadium as he tried his trademark stepovers and feints but proved a handful throughout at the point of United’s attack.
The Portuguese superstar was supported by Paul Pogba, Bruno Fernandes and Mason Greenwood, with no starting place for Jadon Sancho, who has struggled to make an impact since his big-money move from Borussia Dortmund in July.
Ole Gunnar Solskjaer is still trying to work out how best to juggle his impressive forward resources and United are still seeking fluency despite a bright start to the Premier League season.
West Ham proved a stern test for the visitors just five days after 10-man United crashed to a 2-1 defeat against Swiss side Young Boys in their Champions League opener.
Leicester City fell
In another early kick-off match, Brighton beat Leicester City 2-1 to move up to third on the table ahead of the late kick-off between Tottenham and Chelsea.
Neal Maupay converted from the penalty spot with 10 minutes remaining of the first half following a handball by Jannik Vestergaard.
Danny Welbeck doubled the lead five minutes after half-time, flicking a near-post header past Kasper Schmeichel following a Leandro Trossard free-kick.
Leicester pulled a goal back through Jamie Vardy but it was not enough. (AFP)