Incoming world number one Carlos Alcaraz suffered his earliest exit in a tournament since October when he was beaten by Hungarian qualifier Fabian Marozsan in the Italian Open last 32.
Spain’s Alcaraz, who will replace Novak Djokovic at the top of the rankings after the event, lost 6-3 7-6 (7-4).
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It was only the 20-year-old’s second defeat in 22 matches on clay in 2023.
Marozsan, ranked 135th, had never played in the main draw of an ATP Tour event until this week in Rome.
He will play Croatia’s Borna Coric in the fourth round after completing one of the biggest ATP upsets in recent years.